Relationship between erythrocyte fatty acid composition and psychopathology in the Vienna omega-3 study

SW Kim; M Jhon; JM Kim; S Smesny; S Rice; M Berk; CM Klier; PD McGorry; MR Schäfer; GP Amminger

Journal article

Relationship between erythrocyte fatty acid composition and psychopathology in the Vienna omega-3 study

SW Kim, M Jhon, JM Kim, S Smesny, S Rice, M Berk, CM Klier, PD McGorry, MR Schäfer, GP Amminger

Plos One | Published : 2016

DOI: 10.1371/journal.pone.0151417

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Abstract

This study investigated the relationship between erythrocyte membrane fatty acid (FA) levels and the severity of symptoms of individuals at ultra-high risk (UHR) for psychosis. Subjects of the present study consisted of 80 neuroleptic-naive UHR patients. Partial correlation coefficients were calculated between baseline erythrocyte membrane FA levels, measured by gas chromatography, and scores on the Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning Scale, and Montgomery.Asberg Depression Rating Scale (MADRS) after controlling for age, sex, smoking and cannabis use. Subjects were divided into three groups according to the predominance of positive or negative sympt..

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University of Melbourne Researchers

Simon Rice Author

Michael Berk Author

Patrick McGorry Author

Paul Amminger Author

Related Projects (1)

LIPID BIOLOGY FOR PREDICTION AND PREVENTION OF PSYCHOTIC DISORDERS AND PERSISTENT DEPRESSION IN YOUNG PEOPLE

My vision for the next 5 years is to establish ω-3PUFAs as a first-line treatment for indicated prevention of psychosis and persistent depre..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported by grant 03T-315 from the Stanley Medical Research Institute. SWK was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (NRF-2014R1A1A4A01005245). MB was supported by National Health and Medical Research Council Australia (NHMRC) Senior Principal Research Fellowship 1059660. SR was supported by an Early Career Fellowship from the Society for Mental Health Research. GPA was supported by NHMRC Senior Research Fellowship 1080963. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.